What is Preimplantation Genetic Testing (PGT) and Should I Consider It?

Parenthood is one of the most cherished dreams for many couples, but sometimes, underlying genetic factors can make conception or sustaining a pregnancy difficult. This is where Preimplantation Genetic Testing (PGT) steps in, a modern advancement in fertility treatment that helps identify genetic abnormalities in embryos before they are transferred to the uterus. Under the expert care of fertility specialists like Dr Poonam Goyal, many couples have found reassurance and clarity through PGT, ensuring a safer and more confident start to their parenthood journey.

Understanding Preimplantation Genetic Testing (PGT)

PGT is a sophisticated procedure performed during an IVF (In Vitro Fertilisation) cycle. After eggs are retrieved and fertilised with sperm in the lab, embryos are grown for a few days until they reach the blastocyst stage. A few cells from each embryo are then biopsied and sent for genetic analysis. This testing helps identify any chromosomal or genetic abnormalities, allowing only healthy embryos to be selected for transfer.

There are mainly three types of PGT:

• PGT-A (Aneuploidy): Detects chromosomal abnormalities, helping reduce miscarriage risks.

  
  
  
  

• PGT-M (Monogenic): Screens for single-gene disorders such as cystic fibrosis or thalassemia.

  
  
  
  

• PGT-SR (Structural Rearrangements): Identifies chromosomal translocations or structural imbalances.

  
  
  
  

By selecting genetically normal embryos, couples have a higher chance of achieving a successful pregnancy and delivering a healthy baby.

Who Should Consider PGT?

PGT isn’t necessary for every couple undergoing IVF. However, it can be particularly beneficial in the following cases:

• Women above 35, where the risk of chromosomal issues increases.

  
  
  
  

• Couples with a history of recurrent miscarriages.

  
  
  
  

• Individuals with a family history of genetic disorders.

  
  
  
  

• Couples who have experienced failed IVF cycles in the past.

  
  
  
  

• Cases involving male infertility with a high risk of genetic abnormalities.

  
  
  
  

Dr Poonam Goyal often advises couples to consider PGT if their medical history or age factors suggest a potential genetic concern. Her personalised approach ensures that every couple receives clear guidance based on their unique situation, not just general fertility recommendations.

The Benefits of PGT

The biggest advantage of PGT is that it increases the likelihood of a healthy pregnancy by identifying embryos with normal genetic makeup. It also reduces the risk of miscarriage, prevents the transfer of embryos with genetic disorders, and helps avoid difficult decisions later in pregnancy. Additionally, it allows for single embryo transfer, minimising the risk of multiple pregnancies while maintaining high success rates.

PGT can also save time and emotional strain for couples who have faced repeated IVF failures, giving them hope and direction for a successful outcome.

Things to Keep in Mind

While PGT offers remarkable benefits, it’s essential to understand that it doesn’t guarantee pregnancy. The test analyses embryos for known conditions but cannot detect all possible genetic or developmental issues. It also adds to the cost and duration of an IVF cycle, so couples must discuss the pros and cons with their fertility specialist before proceeding.

Conclusion

Preimplantation Genetic Testing is a scientific breakthrough that brings peace of mind and greater success chances for couples planning an IVF journey. With the right guidance and expert care from specialists like Dr Poonam Goyal, couples can make informed decisions about whether PGT suits their fertility goals. Her compassionate approach, supported by advanced reproductive technology, helps couples feel supported and confident as they take their next step toward parenthood, one that begins with science, understanding, and hope.